Longevity mutants across the spectrum of model organisms demonstrate that rates of aging are regulated through genetic control of cellular processes. The study of metazoan model organisms, such as Caenorhabditis elegans, has been instrumental in understanding the role of genetics in the cell biology of aging. Many mutations have been discovered to extend lifespan in organisms of all complexities, from yeast to mammals.
We now have evidence that aging is instead at least in part genetically regulated. One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal-a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.
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